Prostaglandin E2in Induced Sputum Following Oralaspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity
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چکیده
منابع مشابه
Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study
Background. Special regulatory role of eicosanoids has been postulated in aspirin-induced asthma. Objective. To investigate effects of aspirin on exhaled breath condensate (EBC) levels of eicosanoids in patients with asthma. Methods. We determined EBC eicosanoid concentrations using gas chromatography/mass spectrometry (GC-MS) and high-performance liquid chromatography/mass spectrometry (HPLC-M...
متن کاملProstaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity.
BACKGROUND A special regulatory role for prostaglandin E2 has been postulated in aspirin-induced asthma. A study was undertaken to investigate the effects of aspirin on the systemic production of prostaglandin E2 and cysteinyl leucotrienes in patients with asthma. METHODS The urinary concentrations were determined of two main prostaglandin E2 metabolites (13,14-dihydro-15keto-PGE2 using a com...
متن کاملProstaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity
Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist and are always present in patients with aspirin exacerbated respiratory disease (AERD). Although the pathogenic mechanisms of this condition are still unknown, AERD may be due, at least in part, to an imbalance in eicosanoid metabolism (increased production of cysteinyl leukotrienes (CysLTs) and reduced biosynthesis...
متن کاملMontelukast protects against nasal lysine-aspirin challenge in patients with aspirin-induced asthma.
Aspirin-induced asthma (AIA) is associated with increased production of cysteinyl leukotrienes (CysLT). Although leukotriene CysLT1-receptor antagonists improve lower airway outcomes in AIA, their effects and dose-response in the upper airway is less well documented. The present study evaluated the dose-response for montelukast (ML) against nasal lysine-aspirin challenge in patients with AIA. A...
متن کامل287 Nasal Nitric Oxide Levels after Lysine Aspirin Nasal Challenge in Subjects with Aspirin Induced Asthma
100% and pansinusitis. They needed antibiotic scheme. At 2 years in 83.3% had a VAS.7. At 58.3% had pansinusitis. The bronchial relapse did not increase. We determined the presence of VAS. 7 and pansinusitis (OR 1⁄4 4). The bronchial relapse did not influence with increasing VAS (OR 1⁄4 1). Conclusions: Nasal symptoms persistent were secondary to the nasal polyps and pansinusitis with higher le...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2015.12.1217